STRUCTURAL STUDIES OF HUMAN IMMUNOGLOBULINS
نویسندگان
چکیده
منابع مشابه
Structural Studies of Human Immunoglobulins
1. Comparison of peptide maps of the Fc fragments of normal G immunoglobulins and 11 G myeloma proteins of the We (b) type showed them to be very similar except for differences associated with the Gm type. Some additional differences were noted, however, in the Fc fragments of three Vi (c) myeloma proteins. 2. Peptide maps of heavy chains from the same G myeloma proteins differed from each othe...
متن کاملStructural studies of immunoglobulins.
In 1946, when I was starting work as a research student under the supervision of Dr. F. Sanger, the second edition of Karl Lansteiner’s book ‘The Specificity of Seriological Reactions’ (1) reached England. In it was summarised the considerable body of information available on the range of antibody specificity and much of it was Landsteiner’s own work or by others using his basic technique of pr...
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By Alan Solomon W ITHIN the past decade, studies by molecular geneticists on the composition and organization of immunoglobulin (Ig)-coding genes at the DNA level have vastly increased our understanding of the genetic mechanisms responsible for generating antibody diversity and for linking Ig synthesis to cellular differentiation. This new information, which has far-reaching biological and clin...
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The papain-solubilized fragment of the heavy chain of HLA-B7, which is the NH2-terminal part of the whole polypeptide chain, can be divided into three regions by mild acid and cyanogen bromide cleavages. The first 100 amino acids terminating in a methionine residue contain the carbohydrate moiety; this segment is followed by two others of molecular weights 9,999 and 13,000, each containing an i...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1965
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.122.1.1